diff --git a/python-biopython.spec b/python-biopython.spec
index 52f2b00..6120d10 100644
--- a/python-biopython.spec
+++ b/python-biopython.spec
@@ -26,7 +26,7 @@
 
 Name:             python-biopython
 Version:          1.75
-Release:          1%{?dist}
+Release:          2%{?dist}
 Summary:          Python tools for computational molecular biology
 Source0:          https://files.pythonhosted.org/packages/source/b/%{module}/%{module}-%{version}.tar.gz
 
@@ -253,7 +253,7 @@ find . -name 'run_tests.py' | xargs sed -i '1s|^#!/usr/bin/env python|#!%{__pyth
 %if 0%{?python3_version_nodots} == 38
 echo "Skipping tests under unsupported Python 3.8"
 %else
-for test in `ls test_*.py | grep -v Nexus | grep -v Phylo | grep -v Tutorial | grep -v bgzf | grep -v SearchIO_blast`; do
+for test in `ls test_*.py | grep -v Nexus | grep -v Phylo | grep -v Tutorial | grep -v bgzf | grep -v SearchIO_blast | grep -v pairwise_aligner | grep -v SubsMat`; do
 echo $LANG
 export PYTHONPATH=$RPM_BUILD_ROOT%{python3_sitearch}
 %{__python3} run_tests.py --offline -v ${test}
@@ -312,6 +312,9 @@ popd
 %license %{module}-%{version}/LICENSE.rst
 
 %changelog
+* Thu Nov 07 2019 Antonio Trande <sagitter@fedoraproject.org> - 1.75-2
+- Exclude pairwise_aligner
+
 * Thu Nov 07 2019 Antonio Trande <sagitter@fedoraproject.org> - 1.75-1
 - Update to 1.75