diff --git a/python-biopython.spec b/python-biopython.spec
index 757bd0c..2fdf8c6 100644
--- a/python-biopython.spec
+++ b/python-biopython.spec
@@ -1,9 +1,11 @@
-%if 0%{?fedora} || 0%{?rhel} > 7
+%if 0%{?rhel} && 0%{?rhel} > 7
 %global with_python3 1
+%global with_python2 0
 %endif
 
 %if 0%{?rhel} && 0%{?rhel} == 7
 %global with_python3 0
+%global with_python2 1
 %endif
 
 %if 0%{?rhel}
@@ -12,13 +14,23 @@
 %global py2_prefix python2
 %endif
 
+%if 0%{?fedora} && 0%{?fedora} < 30
+%global with_python3 1
+%global with_python2 1
+%endif
+
+%if 0%{?fedora} && 0%{?fedora} >= 30
+%global with_python3 1
+%global with_python2 0
+%endif
+
 %global with_check 1
 
 %global module biopython
 
 Name:             python-biopython
 Version:          1.72
-Release:          2%{?dist}
+Release:          3%{?dist}
 Summary:          Python tools for computational molecular biology
 Source0:          https://files.pythonhosted.org/packages/source/b/%{module}/%{module}-%{version}.tar.gz
 
@@ -29,10 +41,15 @@ License:          MIT and BSD
 URL:              http://www.biopython.org/
 BuildRequires:    gcc
 
+%if 0%{?with_python3_other}
+BuildRequires:  python%{python3_other_pkgversion}-devel
+%endif
+
 %description
 A set of freely available Python tools for computational molecular
 biology.
 
+%if 0%{?with_python2}
 %package -n python2-%{module}
 Summary:  Python tools for computational molecular biology
 %{?python_provide:%python_provide python2-%{module}}
@@ -72,46 +89,69 @@ Requires:         python2-mysql
 BuildRequires:    MySQL-python
 Requires:         MySQL-python
 %endif
-
-%if 0%{?fedora} && 0%{?fedora} < 28
-Requires:    mysql-connector-python
-%endif
-%if 0%{?fedora} && 0%{?fedora} >= 28
 Requires:    %{py2_prefix}-mysql-connector
-%endif
 
 %description -n python2-%{module}
 A set of freely available Python tools for computational molecular
 biology.
+%endif
 
 %if 0%{?with_python3}
-%package -n python3-%{module}
+%package -n python%{python3_pkgversion}-%{module}
 Summary: Python3 tools for computational molecular biology
 
-%{?python_provide:%python_provide python3-%{module}}
+%{?python_provide:%python_provide python%{python3_pkgversion}-%{module}}
 
-BuildRequires:    python3-devel
+BuildRequires:    python%{python3_pkgversion}-devel
 BuildRequires:    flex-devel
-BuildRequires:    python3-reportlab
-BuildRequires:    python3-numpy
-BuildRequires:    python3-mysql
-BuildRequires:    python3-psycopg2
-BuildRequires:    python3-rdflib
-Requires:         python3-networkx
-Requires:         python3-pygraphviz
-Requires:         mysql-connector-python3
-Requires:         python3-reportlab
-Requires:         python3-numpy
-Requires:         python3-mysql
-Requires:         python3-psycopg2
+BuildRequires:    python%{python3_pkgversion}-reportlab
+BuildRequires:    python%{python3_pkgversion}-numpy
+BuildRequires:    python%{python3_pkgversion}-mysql
+BuildRequires:    python%{python3_pkgversion}-psycopg2
+BuildRequires:    python%{python3_pkgversion}-rdflib
+Requires:         python%{python3_pkgversion}-networkx
+Requires:         python%{python3_pkgversion}-pygraphviz
+Requires:         mysql-connector-python%{python3_pkgversion}
+Requires:         python%{python3_pkgversion}-reportlab
+Requires:         python%{python3_pkgversion}-numpy
+Requires:         python%{python3_pkgversion}-mysql
+Requires:         python%{python3_pkgversion}-psycopg2
 Requires:         wise2
-Requires:         python3-rdflib
+Requires:         python%{python3_pkgversion}-rdflib
 
-%description -n python3-%{module}
+%description -n python%{python3_pkgversion}-%{module}
 A set of freely available Python3 tools for computational molecular
 biology.
 %endif
 
+%if 0%{?with_python3_other}
+%package -n python%{python3_other_pkgversion}-%{module}
+Summary: Python3 tools for computational molecular biology
+
+%{?python_provide:%python_provide python%{python3_other_pkgversion}-%{module}}
+
+BuildRequires:    python%{python3_other_pkgversion}-devel
+BuildRequires:    flex-devel
+BuildRequires:    python%{python3_other_pkgversion}-reportlab
+BuildRequires:    python%{python3_other_pkgversion}-numpy
+BuildRequires:    python%{python3_other_pkgversion}-mysql
+BuildRequires:    python%{python3_other_pkgversion}-psycopg2
+BuildRequires:    python%{python3_other_pkgversion}-rdflib
+Requires:         python%{python3_other_pkgversion}-networkx
+Requires:         python%{python3_other_pkgversion}-pygraphviz
+Requires:         mysql-connector-python%{python3_other_pkgversion}
+Requires:         python%{python3_other_pkgversion}-reportlab
+Requires:         python%{python3_other_pkgversion}-numpy
+Requires:         python%{python3_other_pkgversion}-mysql
+Requires:         python%{python3_other_pkgversion}-psycopg2
+Requires:         wise2
+Requires:         python%{python3_other_pkgversion}-rdflib
+
+%description -n python%{python3_other_pkgversion}-%{module}
+A set of freely available Python3 tools for computational molecular
+biology.
+%endif # with_python3_other
+
 %package doc
 Summary: PDF and HTML documentation of %{module}
 BuildArch: noarch
@@ -121,9 +161,7 @@ PDF/HTML documentation of %{module}.
 %prep
 %setup -qc
 
-mv %{module}-1.72 python2
-pushd python2
-
+pushd %{module}-1.72
 # remove all execute bits from documentation and fix line endings
 find Scripts -type f -exec chmod -x {} 2>/dev/null ';'
 find Doc -type f -exec chmod -x {} 2>/dev/null ';'
@@ -135,21 +173,37 @@ find Bio -type f -exec chmod -x {} 2>/dev/null ';'
 find Bio -type f -name "*.py" -exec sed -i '/^#![ ]*\/usr\/bin\/.*$/ d' {} 2>/dev/null ';'
 popd
 
+%if 0%{?with_python2}
+cp -a %{module}-%{version} python2
+%endif
+
 %if 0%{?with_python3}
-cp -a python2 python3
+cp -a %{module}-%{version} python3
 %endif # with_python3
 
+%if 0%{?with_python3_other}
+cp -a %{module}-%{version} python%{python3_other_pkgversion}
+%endif # with_python3_other
+
 %build
+%if 0%{?with_python2}
 pushd python2
-CFLAGS="$RPM_OPT_FLAGS -Wl,-z,relro -Wl,-z,now" %{__python2} setup.py build --executable="%{__python2} -s"
+%py2_build
 popd
+%endif
 
 %if 0%{?with_python3}
 pushd python3
-CFLAGS="$RPM_OPT_FLAGS -Wl,-z,relro -Wl,-z,now" %{__python3} setup.py build --executable="%{__python3} -s"
+%py3_build
 popd
 %endif # with_python3
 
+%if 0%{?with_python3_other}
+pushd python%{python3_other_pkgversion}
+%py3_other_build
+popd
+%endif # with_python3_other
+
 %install
 %if 0%{?with_python3}
 pushd python3
@@ -157,15 +211,24 @@ pushd python3
 popd
 %endif
 
+%if 0%{?with_python3_other}
+pushd python%{python3_other_pkgversion}
+%{__python3_other} setup.py install -O1 --skip-build --root=$RPM_BUILD_ROOT --install-data=%{_datadir}/python-biopython
+popd
+%endif
+
+%if 0%{?with_python2}
 pushd python2
 %{__python2} setup.py install -O1 --skip-build --root=$RPM_BUILD_ROOT --install-data=%{_datadir}/python-biopython
 popd
+%endif
 
 ##DocTest cannot be executed
 ##https://github.com/biopython/biopython/issues/669
 ##http://lists.open-bio.org/pipermail/biopython-dev/2014-May/020541.html
 %if 0%{?with_check}
 %check
+%if 0%{?with_python2}
 pushd python2
 export PYTHONPATH=$RPM_BUILD_ROOT%{python2_sitearch}
 find . -name 'run_tests.py' | xargs sed -i '1s|^#!/usr/bin/env python|#!%{__python2}|'
@@ -173,6 +236,7 @@ for test in `ls test_*.py | grep -v Tutorial`; do
 %{__python2} run_tests.py --offline -v ${test}
 done
 popd
+%endif
 
 # See https://github.com/biopython/biopython/issues/855
 %if 0%{?with_python3}
@@ -185,20 +249,32 @@ export PYTHONPATH=$RPM_BUILD_ROOT%{python3_sitearch}
 done
 popd
 %endif
-%endif
 
+# See https://github.com/biopython/biopython/issues/855
+%if 0%{?with_python3_other}
+pushd python%{python3_other_pkgversion}/Tests
+find . -name 'run_tests.py' | xargs sed -i '1s|^#!/usr/bin/env python|#!%{__python3_other}|'
+for test in `ls test_*.py | grep -v Nexus | grep -v Phylo | grep -v Tutorial | grep -v bgzf`; do
+echo $LANG
+export PYTHONPATH=$RPM_BUILD_ROOT%{python3_other_sitearch}
+%{__python3_other} run_tests.py --offline -v ${test}
+done
+popd
+%endif # with_python3_other
+%endif # with_check
+
+%if 0%{?with_python2}
 %files -n python2-%{module}
-%{!?_licensedir:%global license %doc}
 %doc python2/Scripts
 %doc python2/CONTRIB python2/DEPRECATED python2/NEWS python2/README
 %license python2/LICENSE
 %{python2_sitearch}/*egg-info
 %{python2_sitearch}/Bio/
 %{python2_sitearch}/BioSQL/
+%endif
 
 %if 0%{?with_python3}
-%files -n python3-%{module}
-%{!?_licensedir:%global license %doc}
+%files -n python%{python3_pkgversion}-%{module}
 %doc python3/Scripts
 %doc python3/CONTRIB python3/DEPRECATED python3/NEWS python3/README
 %license python3/LICENSE
@@ -207,12 +283,25 @@ popd
 %{python3_sitearch}/BioSQL/
 %endif
 
+%if 0%{?with_python3_other}
+%files -n python%{python3_other_pkgversion}-%{module}
+%doc python%{python3_other_pkgversion}/Scripts
+%doc python%{python3_other_pkgversion}/CONTRIB python%{python3_other_pkgversion}/DEPRECATED python%{python3_other_pkgversion}/NEWS python%{python3_other_pkgversion}/README
+%license python%{python3_other_pkgversion}/LICENSE
+%{python3_other_sitearch}/*egg-info
+%{python3_other_sitearch}/Bio/
+%{python3_other_sitearch}/BioSQL/
+%endif
+
 %files doc
-%{!?_licensedir:%global license %doc}
-%doc python2/Doc
-%license python2/LICENSE
+%doc %{module}-1.72/Doc
+%license %{module}-1.72/LICENSE
 
 %changelog
+* Wed Aug 22 2018 Antonio Trande <sagitter@fedoraproject.org> - 1.72-3
+- Deprecate Python2 on fedora 30+
+- Prepare SPEC file for Python3-modules packaging on epel7
+
 * Fri Jul 13 2018 Fedora Release Engineering <releng@fedoraproject.org> - 1.72-2
 - Rebuilt for https://fedoraproject.org/wiki/Fedora_29_Mass_Rebuild